The blood–brain barrier (BBB) is one of the most complex and selective barriers in the
human organism. Its role is to protect the brain and preserve the homeostasis of the central …

Porous membranes enable the partitioning of cellular microenvironments in vitro, while still
allowing physical and biochemical crosstalk between cells, a feature that is often necessary …

In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

Introduction: The blood-brain barrier (BBB) is a dynamic biological interface which actively
controls the passage of substances between the blood and the central nervous system …

Here we report on the development of a breakthrough micro fluidic human in vitro
cerebrovascular barrier (CVB) model featuring stem cell-derived brain-like endothelial cells …

Brain homeostasis relies on the selective permeability property of the blood brain barrier
(BBB). The BBB is formed by a continuous endothelium that regulates exchange between …

The blood–brain barrier (BBB) is a cellular and physical barrier with a crucial role in
homeostasis of the brain extracellular environment. It controls the imports of nutrients to the …

An important goal of biomedical research is to translate basic research findings into practical
clinical implementation. Despite the advances in the technology used in drug discovery, the …

The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial
cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding …

Background The brain barriers establish compartments in the central nervous system (CNS)
that significantly differ in their communication with the peripheral immune system. In this …