Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

M Zhang, S Cui, B Mao, Q Zhang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …

[HTML][HTML] Anti-inflammatory properties of diet: role in healthy aging

K Stromsnes, AG Correas, J Lehmann, J Gambini… - Biomedicines, 2021 - mdpi.com
Inflammation is a physiological process involved in the defenses of the body and the repair
of tissues. It is acutely activated by infections, trauma, toxins, or allergic reactions. However …

Cartilage Lacuna‐Inspired Microcarriers Drive Hyaline Neocartilage Regeneration

SL Ding, XY Zhao, W Xiong, LF Ji, MX Jia… - Advanced …, 2023 - Wiley Online Library
Cartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in
hyaline cartilage regeneration, yet current approaches have limited success at reconstituting …

Ellagic acid‐derived urolithins as modulators of oxidative stress

J Djedjibegovic, A Marjanovic… - … medicine and cellular …, 2020 - Wiley Online Library
Oxidative stress is a state of excess of prooxidative species relative to the antioxidant
defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this …

[HTML][HTML] Immunomodulatory role of urolithin A on metabolic diseases

AM Toney, D Fox, V Chaidez, AE Ramer-Tait, S Chung - Biomedicines, 2021 - mdpi.com
Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as
pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic …

A mechanistic insight into the biological activities of urolithins as gut microbial metabolites of ellagitannins

SH Hasheminezhad, M Boozari… - Phytotherapy …, 2022 - Wiley Online Library
Urolithins are the gut metabolites produced from ellagitannin‐rich foods such as
pomegranates, tea, walnuts, as well as strawberries, raspberries, blackberries, and …

Regulatory effects of IL-1β in the interaction of GBM and tumor-associated monocyte through VCAM-1 and ICAM-1

CK Shen, BR Huang, WL Yeh, CW Chen, YS Liu… - European journal of …, 2021 - Elsevier
Glioblastoma (GBM) is the most common and lethal brain tumor with high inflammation.
GBM cells infiltrate microglia and macrophages and are surrounded by pro-inflammatory …

Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study

Y Shen, L Teng, Y Qu, Y Huang, Y Peng, M Tang, Q Fu - Inflammation, 2023 - Springer
Osteoarthritis (OA), a common degenerative joint disease, is characterized by the
progressive degradation of articular cartilage and inflammation. Hederagenin (HE) is a …

[HTML][HTML] Exploration of anti‑osteosarcoma activity of asiatic acid based on network pharmacology and in vitro experiments

H Pang, H Wu, Z Zhan, T Wu… - Oncology …, 2024 - build.spandidos-publications.com
Osteosarcomas are malignant bone tumors that typically originate in the epiphyses of the
long bones of the extremities in adolescents. Asiatic acid has been reported to possess anti …

[HTML][HTML] Urolithins: A prospective alternative against brain aging

L An, Q Lu, K Wang, Y Wang - Nutrients, 2023 - mdpi.com
The impact of host–microbiome interactions on cognitive health and disease has received
increasing attention. Microbial-derived metabolites produced in the gut are one of crucial …