Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Scientific, sustainability and regulatory challenges of cultured meat

MJ Post, S Levenberg, DL Kaplan, N Genovese, J Fu… - Nature Food, 2020 - nature.com
Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

L Chen, DV Zhernakova, A Kurilshikov… - Nature medicine, 2022 - nature.com
The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …

[PDF][PDF] Metabolomics and isotope tracing

C Jang, L Chen, JD Rabinowitz - Cell, 2018 - cell.com
Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …

Genomics and pathotypes of the many faces of Escherichia coli

J Geurtsen, M de Been, E Weerdenburg… - FEMS Microbiology …, 2022 - academic.oup.com
Escherichia coli is the most researched microbial organism in the world. Its varied impact on
human health, consisting of commensalism, gastrointestinal disease, or extraintestinal …

[PDF][PDF] A map of protein-metabolite interactions reveals principles of chemical communication

I Piazza, K Kochanowski, V Cappelletti, T Fuhrer… - Cell, 2018 - cell.com
Metabolite-protein interactions control a variety of cellular processes, thereby playing a
major role in maintaining cellular homeostasis. Metabolites comprise the largest fraction of …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis

C Wieder, C Frainay, N Poupin… - PLoS computational …, 2021 - journals.plos.org
Over-representation analysis (ORA) is one of the commonest pathway analysis approaches
used for the functional interpretation of metabolomics datasets. Despite the widespread use …

Pathway Tools version 23.0 update: software for pathway/genome informatics and systems biology

PD Karp, PE Midford, R Billington… - Briefings in …, 2021 - academic.oup.com
Motivation Biological systems function through dynamic interactions among genes and their
products, regulatory circuits and metabolic networks. Our development of the Pathway Tools …

Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

I Roberts, M Wright Muelas, JM Taylor, AS Davison… - Metabolomics, 2022 - Springer
Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of
viral nucleic acid sequences. Properties of the host response are not measured but are key …