Site-selective modification strategies in antibody–drug conjugates
SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins
Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …
structures and functions in complicated cellular environments and accomplishing semi …
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
Protein conjugates are valuable tools for studying biological processes or producing
therapeutics, such as antibody–drug conjugates. Despite the development of several protein …
therapeutics, such as antibody–drug conjugates. Despite the development of several protein …
Site-specific bioconjugation approaches for enhanced delivery of protein therapeutics and protein drug carriers
Proteins have the capacity to treat a multitude of diseases both as therapeutics and as drug
carriers due to their complex functional properties, specificity toward binding partners …
carriers due to their complex functional properties, specificity toward binding partners …
Protein engineering strategies for improved pharmacokinetics
Protein therapeutics have gained momentum in recent years and become a pillar in treating
many diseases and the only choice in several ailments. Protein therapeutics are highly …
many diseases and the only choice in several ailments. Protein therapeutics are highly …
Harnessing sortase A transpeptidation for advanced targeted therapeutics and vaccine engineering
The engineering of potent prophylactic and therapeutic complexes has always required
careful protein modification techniques with seamless capabilities. In this light, methods that …
careful protein modification techniques with seamless capabilities. In this light, methods that …
Photofunctional cyclometalated iridium (III) polypyridine complexes bearing a perfluorobiphenyl moiety for bioconjugation, bioimaging, and phototherapeutic …
In this article, we report the design, synthesis, and characterization of a series of
cyclometalated iridium (III) polypyridine complexes containing a perfluorobiphenyl (PFBP) …
cyclometalated iridium (III) polypyridine complexes containing a perfluorobiphenyl (PFBP) …
π-Clamp-mediated homo-and heterodimerization of single-domain antibodies via site-specific homobifunctional conjugation
RJ Taylor, M Aguilar Rangel, MB Geeson… - Journal of the …, 2022 - ACS Publications
Post-translational protein–protein conjugation produces bioconjugates that are unavailable
via genetic fusion approaches. A method for preparing protein–protein conjugates using π …
via genetic fusion approaches. A method for preparing protein–protein conjugates using π …
Site-specific dual-labeling of a VHH with a chelator and a photosensitizer for nuclear imaging and targeted photodynamic therapy of EGFR-positive tumors
E Renard, E Collado Camps, C Canovas, A Kip… - Cancers, 2021 - mdpi.com
Simple Summary Variable domains of heavy chain only antibodies are small proteins that
can be used for tumor imaging and therapy upon conjugation of functional groups. As …
can be used for tumor imaging and therapy upon conjugation of functional groups. As …
Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering
CM Le Gall, JMS van der Schoot… - Bioconjugate …, 2021 - ACS Publications
Functionalized antibodies and antibody fragments have found applications in the fields of
biomedical imaging, theranostics, and antibody–drug conjugates (ADC). In addition …
biomedical imaging, theranostics, and antibody–drug conjugates (ADC). In addition …