Complicated role of exercise in modulating memory: a discussion of the mechanisms involved

M Ebrahimnejad, P Azizi, V Alipour… - Neurochemical …, 2022 - Springer
Evidence has shown the beneficial effects of exercise on learning and memory. However,
many studies have reported controversial results, indicating that exercise can impair …

Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans

M Kodali, T Jankay, AK Shetty, DS Reddy - Psychopharmacology, 2023 - Springer
This article describes the pathophysiology and potential treatments for Gulf War Illness
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …

[HTML][HTML] Role of microglia, decreased neurogenesis and oligodendrocyte depletion in long COVID-mediated brain impairments

ZYD Wei, K Liang, AK Shetty - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a recent
worldwide coronavirus disease-2019 (COVID-19) pandemic. SARS-CoV-2 primarily causes …

Exercise Intervention Modulates Synaptic Plasticity by Inhibiting Excessive Microglial Activation via Exosomes

C Li, J Hu, W Liu, C Ke, C Huang, Y Bai… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Exosomes can activate microglia to modulate neural activity and synaptic
plasticity by phagocytosis of neural spines or synapses. Our previous research found that an …

Brain-specific increase in leukotriene signaling accompanies chronic neuroinflammation and cognitive impairment in a model of Gulf war illness

S Attaluri, R Upadhya, M Kodali, LN Madhu… - Frontiers in …, 2022 - frontiersin.org
Persistent cognitive impairment is a primary central nervous system-related symptom in
veterans afflicted with chronic Gulf War Illness (GWI). Previous studies in a rat model have …

Association between behavioural risks and Alzheimer's disease: Elucidated with an integrated analysis of gene expression patterns and molecular mechanisms

D Li, H Yang, M Lyu, L Zhou, Y Zhang, C Kang… - Neuroscience & …, 2023 - Elsevier
Alzheimer's disease (AD) remains a global health challenge. Previous studies have reported
linkages between AD and multiple behavioural risk exposures, however, the underlying …

Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease

LN Madhu, Y Somayaji, AK Shetty - Ageing research reviews, 2022 - Elsevier
Strategies proficient for relieving cognitive impairments in aging and Alzheimer's disease
(AD) have an enormous impact. Regular physical exercise (PE) can prevent age-related …

Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic …

M Li, J Xu, L Li, L Zhang, Z Zuo, Y Feng, X He… - Experimental …, 2024 - Elsevier
Background and objectives Chronic colitis exacerbates neuroinflammation, contributing to
cognitive impairment during aging, but the mechanism remains unclear. The polarity …

The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness

LT Michalovicz, KA Kelly, DB Miller, K Sullivan… - Life sciences, 2021 - Elsevier
Aims Growing evidence suggests that Gulf War Illness (GWI) is the result of underlying
neuroimmune dysfunction. For example, previously we found that several GWI-relevant …

Neurogenesis and chronic neurobehavioral outcomes are partially improved by vagus nerve stimulation in a mouse model of Gulf War illness

J Iannucci, D Nizamutdinov, LA Shapiro - Neurotoxicology, 2022 - Elsevier
Gulf War illness (GWI) is a chronic, multi-symptom disorder that has impacted approximately
one third of Gulf War veterans. GWI and its symptoms have been linked to the exposure to …