Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall.
These modified lipoproteins activate resident macrophages and the recruitment of monocyte …

Atherosclerosis is characterized by lipid accumulation and chronic inflammation of the
arterial wall, and its main complications—myocardial infarction and ischemic stroke …

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix
(ECM) fragmentation and inflammation. However, the mechanisms by which these events …

Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque,
represent the major cause of morbidity and mortality in patients. Growing evidence suggests …

Objective—Although it is accepted that macrophage glycolysis is upregulated under hypoxic
conditions, it is not known whether this is linked to a similar increase in macrophage …

The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels
the development of atherosclerosis. However, the mechanism that regulates the formation of …

During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation
that contributes to type II diabetes. Evidence suggests that the rewiring of cellular …

Atherosclerosis is a complex chronic disease. The accumulation of myeloid cells in the
arterial intima, including macrophages and dendritic cells (DCs), is a feature of early stages …