Organellar homeostasis and innate immune sensing
A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …
The cytoplasmic peptide: N-glycanase (NGLY1)—Structure, expression and cellular functions
T Suzuki, C Huang, H Fujihira - Gene, 2016 - Elsevier
NGLY1/Ngly1 is a cytosolic peptide: N-glycanase, ie. de-N-glycosylating enzyme acting on
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …
Signaling through plant lectins: modulation of plant immunity and beyond
S Van Holle, EJM Van Damme - Biochemical Society …, 2018 - portlandpress.com
Lectins constitute an abundant group of proteins that are present throughout the plant
kingdom. Only recently, genome-wide screenings have unraveled the multitude of different …
kingdom. Only recently, genome-wide screenings have unraveled the multitude of different …
Generation and degradation of free asparagine-linked glycans
Y Harada, H Hirayama, T Suzuki - Cellular and molecular life sciences, 2015 - Springer
Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
The cytoplasmic peptide:N-glycanase (Ngly1)—basic science encounters a human genetic disorder
T Suzuki - The journal of biochemistry, 2015 - academic.oup.com
Abstract Peptide: N-glycanase (PNGase) is a de-N-glycosylating enzyme that cleaves intact
N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in …
N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in …
Identifying the targets and functions of N-linked protein glycosylation in Campylobacter jejuni
JA Cain, AL Dale, Z Sumer-Bayraktar, N Solis… - Molecular omics, 2020 - pubs.rsc.org
Campylobacter jejuni is a major cause of bacterial gastroenteritis in humans that is primarily
associated with the consumption of inadequately prepared poultry products, since the …
associated with the consumption of inadequately prepared poultry products, since the …
Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide
Oligosaccharyltransferase (OST) is a key enzyme of the N-glycosylation pathway, where it
catalyzes the transfer of a glycan from a lipid-linked oligosaccharide (LLO) to an acceptor …
catalyzes the transfer of a glycan from a lipid-linked oligosaccharide (LLO) to an acceptor …
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis
H Lu, CS Fermaintt, NA Cherepanova… - Proceedings of the …, 2018 - National Acad Sciences
Oligosaccharyltransferases (OSTs) N-glycosylate proteins by transferring oligosaccharides
from lipid-linked oligosaccharides (LLOs) to asparaginyl residues of Asn-Xaa-Ser/Thr …
from lipid-linked oligosaccharides (LLOs) to asparaginyl residues of Asn-Xaa-Ser/Thr …
Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells
Y Harada, Y Masahara-Negishi, T Suzuki - Glycobiology, 2015 - academic.oup.com
During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable
amounts of free oligosaccharides (fOSs) in the cytosol. It is generally assumed that such …
amounts of free oligosaccharides (fOSs) in the cytosol. It is generally assumed that such …
Physiological and molecular functions of the cytosolic peptide: N-glycanase
H Hirayama, A Hosomi, T Suzuki - Seminars in cell & developmental …, 2015 - Elsevier
Abstract Peptide: N-glycanase (PNGase) is a deglycosylating enzyme that acts on N-
glycoproteins. A growing evidence exists to indicate that the cytosolic form of PNGase, which …
glycoproteins. A growing evidence exists to indicate that the cytosolic form of PNGase, which …