Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Sepsis results in a deluge of pro-and anti-inflammatory cytokines, leading to lymphopenia
and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in …

As treatment of the early, inflammatory phase of sepsis improves, post-sepsis
immunosuppression and secondary infection have increased in importance. How early …

The early immune response to microbes is dominated by the recruitment of neutrophils
whose primary function is to clear invading pathogens. However, there is emerging …

Sepsis is a systemic inflammatory response syndrome due to infection. The incidence rate is
estimated to be up to 19 million cases worldwide per year and the number of cases is rising …

Background Sepsis is a leading cause of death among critically ill patients, which is defined
as life-threatening organ dysfunction caused by a deregulated host immune response to …

Background: Sepsis is marked by a dysregulated immune response to an infection. Invariant
natural killer T cells (iNKT cells) are a pluripotent lymphocyte subpopulation capable of …

Background Sepsis and the ensuing immune dysfunction continue to be major contributors
to neonatal morbidity and mortality. Neonatal sepsis also is associated with profound …

Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …

Sepsis is characterized by a severe systemic inflammatory response to infection that is
associated with high morbidity and mortality despite optimal care. Invariant natural killer T …