Therapeutic hypothermia for neonatal hypoxic–ischemic encephalopathy–where to from here?

JO Davidson, G Wassink, LG Van den Heuij… - Frontiers in …, 2015 - frontiersin.org
Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

All roads lead to disconnection?–Traumatic axonal injury revisited

A Büki, JT Povlishock - Acta neurochirurgica, 2006 - Springer
Traumatic brain injury (TBI) evokes widespread/diffuse axonal injury (TAI) significantly
contributing to its morbidity and mortality. While classic theories suggest that traumatically …

Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy

LF Chalak, PJ Sánchez, B Adams-Huet… - The Journal of …, 2014 - Elsevier
Objective To evaluate serum neuronal and inflammatory biomarkers to determine whether
measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic …

A review of progress in understanding the pathophysiology and treatment of brain edema

A Marmarou - Neurosurgical focus, 2007 - thejns.org
Object Brain edema resulting from traumatic brain injury (TBI) or ischemia if uncontrolled
exhausts volume reserve and leads to raised intracranial pressure and brain herniation. The …

RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 7: Clinical guidelines

DJ Fletcher, M Boller, BM Brainard… - Journal of Veterinary …, 2012 - Wiley Online Library
Objective To present a series of evidence‐based, consensus guidelines for veterinary CPR
in dogs and cats. Design Standardized, systematic evaluation of the literature, categorization …

Hypothermic neuroprotection

AJ Gunn, M Thoresen - NeuroRx, 2006 - Elsevier
The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage

H Zhao, GK Steinberg… - Journal of Cerebral Blood …, 2007 - journals.sagepub.com
Mild or moderate hypothermia is generally thought to block all changes in signaling events
that are detrimental to ischemic brain, including ATP depletion, glutamate release, Ca2+ …

Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic …

T Els, E Oehm, S Voigt, J Klisch, A Hetzel… - Cerebrovascular …, 2006 - karger.com
Introduction: Both for hemicraniectomy and for hypothermia, several reports describe a
beneficial effect in patients with malignant supratentorial cerebral ischemia. We compared …

A randomized controlled trial comparing the Arctic Sun to standard cooling for induction of hypothermia after cardiac arrest

KJ Heard, MA Peberdy, MR Sayre, A Sanders… - Resuscitation, 2010 - Elsevier
CONTEXT: Hypothermia improves neurological outcome for comatose survivors of out-of-
hospital cardiac arrest. Use of computer controlled high surface area devices for cooling …

Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?

A Davies, G Wassink, L Bennet, AJ Gunn… - Neural regeneration …, 2019 - journals.lww.com
Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and
disability. Therapeutic hypothermia significantly reduces death and major disability …