Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel evolutionarily
conserved protein present in both vertebrate and invertebrate species. MANF shows distinct …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal proteins that confer …

Stroke is a devastating medical condition with no treatment to hasten recovery. Its abrupt
nature results in cataclysmic changes in the affected tissues. Resident cells fail to cope with …

Age-related decline in skeletal muscle regenerative capacity is multifactorial, yet the
contribution of immune dysfunction to regenerative failure is unknown. Macrophages are …

The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to
retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However …

Bacterial myocarditis is a key cause leading to myocardial damage and cardiac dysfunction.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been found to be an anti …

Alcohol exposure has detrimental effects on both the developing and mature brain.
Endoplasmic reticulum (ER) stress is one of the mechanisms that contributes to alcohol …

Inherited and age-associated vision loss is often associated with degeneration of the cells of
the retina, the light-sensitive layer at the back of the eye. The mammalian retina, being a …

Alcohol exposure during pregnancy is harmful to the fetus and causes a wide range of long-
lasting physiological and neurocognitive impairments, collectively referred to as fetal alcohol …

Excessive alcohol exposure can cause neurobehavioral deficits and structural alterations in
the brain. Emerging research evidence suggests that endoplasmic reticulum (ER) stress …