Sjögren's syndrome is a chronic autoimmune disease characterized by ocular and oral
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …

Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types.
Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological …

Background Primary Sjogren's syndrome (pSS) is a slowly progressive, inflammatory
autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal …

Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of
exocrine glands including salivary and lachrymal glands responsible for the classical dry …

Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the
loss of self-tolerance mechanisms in various autoimmune diseases, including primary …

Sjögren's syndrome (SS) is characterized by B cell hyperactivity documented by the
production of plethora of autoantibodies and a strong tendency for NHL of B cell origin …

BMP6 is a central cytokine in the induction of Sjögren's syndrome–associated (SS-
associated) secretory hypofunction. However, the upstream initiation leading to the …

Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions
and maintain peripheral self-tolerance, playing an essential role in maintaining immune …

Objective Salivary gland epithelial cells (SGECs) are key cellular drivers in the pathogenesis
of primary Sjögren's syndrome (SS); however, the mechanisms sustaining SGEC activation …

There are some challenges and unmet needs in the early diagnosis and management of
Sjögren's syndrome (SjS) such as prominent glandular dysfunction at diagnosis and long …