Glycols: The ubiquitous solvent for dermal formulations

HL Yu, CF Goh - European Journal of Pharmaceutics and …, 2024 - Elsevier
Glycols stand out as one of the most commonly employed safe and effective excipients for
pharmaceutical and cosmeceutical products. Their widespread adoption can be attributed to …

Advanced structural characterisation of pharmaceuticals using nano-thermal analysis (nano-TA)

CF Goh, ME Lane - Advanced Drug Delivery Reviews, 2022 - Elsevier
The production of drug delivery systems fabricated at the nano scale comes with the
challenges of identifying reliable characterisation tools, especially for solid dosage forms. A …

Electrospun cellulose acetate/polyvinylpyrrolidone fiber mats as potential cosmetic under-eye masks for caffeine delivery

P Tipduangta, W Watcharathirawongs… - Journal of Drug Delivery …, 2023 - Elsevier
Cosmetic products for skin aging including infraorbital dark circles are getting popular.
Caffeine incorporation into beauty skin masks is beneficial for this concern but the topical …

Cellulose hydrogel development from unbleached oil palm biomass pulps for dermal drug delivery

LC Wong, JH Poh, WT Tan, BK Khor… - International Journal of …, 2023 - Elsevier
Hydrogels are an attractive platform for drug delivery to the skin. Current cellulose hydrogel
developments commonly focus on readily available bleached woody cellulose. Considering …

Crystals and crystallization in drug delivery design

LS Taylor, DE Braun, JW Steed - Crystal Growth & Design, 2021 - ACS Publications
The solid form of a pharmaceutical has a tremendous impact on its materials properties,
particularly solubility, dissolution rate, morphology, and tableting characteristics. Poor …

In vitro–in vivo correlation in dermal delivery: the role of excipients

A Patel, F Iliopoulos, PJ Caspers, GJ Puppels… - Pharmaceutics, 2021 - mdpi.com
The composition of topical and transdermal formulations is known to determine the rate and
the extent of drug delivery to and through the skin. However, to date, the role of excipients in …

Determining topical product bioequivalence with stimulated Raman scattering microscopy

F Iliopoulos, D Tu, IJ Pence, X Li, P Ghosh… - Journal of Controlled …, 2024 - Elsevier
Generic drugs are essential for affordable medicine and improving accessibility to
treatments. Bioequivalence (BE) is typically demonstrated by assessing a generic product's …

Confocal Raman spectroscopy for assessing bioequivalence of topical formulations

F Iliopoulos, CF Tang, Z Li, A Rahma, ME Lane - Pharmaceutics, 2023 - mdpi.com
The evaluation of bioequivalence (BE) for topical dermatological drug products is
challenging, and there has been significant interest from regulatory authorities in developing …

Profiling skin penetration using PEGylated emulsifiers as penetration enhancers via confocal Raman spectroscopy and fluorescence spectroscopy

Y Liu, DJ Lunter - European Journal of Pharmaceutics and …, 2021 - Elsevier
Non-ionic emulsifiers have been continuous research focus in skin analysis. With the aim of
finding their role as penetration enhancers in dermal drug delivery systems, PEGylated …

Dermal delivery of diclofenac sodium—In vitro and in vivo studies

F Iliopoulos, CF Goh, T Haque, A Rahma, ME Lane - Pharmaceutics, 2022 - mdpi.com
Previously, we reported the use of confocal Raman spectroscopy (CRS) as a novel non-
invasive approach to determine drug disposition in the skin in vivo. Results obtained by CRS …