Predictors of outcomes in hypoxic-ischemic encephalopathy following hypothermia: a meta-analysis

S Ouwehand, LCA Smidt, J Dudink, MJNL Benders… - Neonatology, 2020 - karger.com
Introduction: Prediction of neurodevelopmental outcome in infants with hypoxic-ischemic
encephalopathy remains an important challenge. Various studies have shown that the …

[HTML][HTML] Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy

MC Chiang, YJ Jong, CH Lin - Pediatrics & Neonatology, 2017 - Elsevier
Therapeutic hypothermia (TH) is a recommended regimen for newborn infants who are at or
near term with evolving moderate-to-severe hypoxic ischemic encephalopathy (HIE). The …

[HTML][HTML] Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study

PJ Lally, P Montaldo, V Oliveira, A Soe… - The Lancet …, 2019 - thelancet.com
Background In neonatal encephalopathy, the clinical manifestations of injury can only be
reliably assessed several years after an intervention, complicating early prognostication and …

Early identification of brain injury in infants with hypoxic ischemic encephalopathy at high risk for severe impairments: accuracy of MRI performed in the first days of life

T Agut, M León, M Rebollo, J Muchart, G Arca… - BMC pediatrics, 2014 - Springer
Abstract Background Despite therapeutic hypothermia 30-70% of newborns with moderate
or severe hypoxic ischemic encephalopathy will die or survive with significant long-term …

White matter tract integrity and developmental outcome in newborn infants with hypoxic‐ischemic encephalopathy treated with hypothermia

AN Massaro, I Evangelou, A Fatemi… - … Medicine & Child …, 2015 - Wiley Online Library
Aim To determine whether corpus callosum (CC) and corticospinal tract (CST) diffusion
tensor imaging (DTI) measures relate to developmental outcome in encephalopathic …

Comparison of predictive values of magnetic resonance biomarkers based on scan timing in neonatal encephalopathy following therapeutic hypothermia

J Shibasaki, T Niwa, A Piedvache, M Tomiyasu… - The Journal of …, 2021 - Elsevier
Objective To determine the optimal quantitative magnetic resonance (MR) biomarker in
neonatal encephalopathy following therapeutic hypothermia based on scan timing. Study …

Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic‐ischemic …

JK Lee, D Liu, D Jiang, E Kulikowicz… - Journal of …, 2021 - Wiley Online Library
The specific cytopathology that causes abnormal fractional anisotropy (FA) and mean
diffusivity (MD) from diffusion tensor imaging (DTI) after neonatal hypoxia‐ischemia (HI) is …

Interplay of brain structure and function in neonatal congenital heart disease

A Birca, VA Vakorin, P Porayette… - Annals of clinical …, 2016 - Wiley Online Library
Objective To evaluate whether structural and microstructural brain abnormalities in neonates
with congenital heart disease (CHD) correlate with neuronal network dysfunction measured …

Neurodevelopmental effect of intracranial hemorrhage observed in hypoxic ischemic brain injury in hypothermia-treated asphyxiated neonates-an MRI study

A Lakatos, M Kolossváry, M Szabó, Á Jermendy… - BMC pediatrics, 2019 - Springer
Background Identification of early signs of hypoxic ischemic encephalopathy (HIE) with
magnetic resonance imaging (MRI) has proven of prognostic significance. Yet, the …

Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 48 h predicts cell death following varied neuroprotective interventions in a piglet model of …

R Pang, KA Martinello, C Meehan… - Frontiers in …, 2020 - frontiersin.org
Despite therapeutic hypothermia, survivors of neonatal encephalopathy have high rates of
adverse outcome. Early surrogate outcome measures are needed to speed up the …