Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …

Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early
diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition …

Crosstalk between organs is crucial for controlling numerous homeostatic systems (eg
energy balance, glucose metabolism and immunity). Several pathological conditions, such …

Growing evidence supports the role of gut microbiota in the development of obesity, type 2
diabetes, and low-grade inflammation. The endocrine activity of adipose tissue has been …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

Both acute and chronic apelin treatment have been shown to improve insulin sensitivity in
mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related …

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …

The prevalence of type 2 diabetes (T2D) is rapidly increasing. This is strongly related to the
contemporary lifestyle changes that have resulted in increased rates of overweight …

Objective: Apelin is an adipokine which plays a role in the regulation of glucose
homeostasis and may contribute to the link between increased adipose tissue mass and …