Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF

C Patel, E André-Joyaux, JA Leitch… - Science, 2023 - science.org
All fluorochemicals—including elemental fluorine and nucleophilic, electrophilic, and radical
fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and …

Covalent drug discovery using sulfur (VI) fluoride exchange warheads

H Huang, LH Jones - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Introduction Covalent drug discovery has traditionally focused on targeting cysteine, but the
amino acid is often absent in protein binding sites. This review makes the case to move …

Synthesis of sulfonyl, sulfonimidoyl, and sulfoxyl fluorides under solvent-free mechanochemical conditions in a mixer mill by imidazole-to-fluorine exchange

MT Passia, MM Amer, J Demaerel… - … Sustainable Chemistry & …, 2023 - ACS Publications
A sustainable, mechanochemical procedure for the synthesis of sulfur (VI) fluorides starting
from readily available sulfur (VI) 2-methylimidazoles as stable S (VI) precursors has been …

Asymmetric synthesis of sulfoximines, sulfonimidoyl fluorides and sulfonimidamides enabled by an enantiopure bifunctional S (VI) reagent

S Teng, ZP Shultz, C Shan, L Wojtas, JM Lopchuk - Nature Chemistry, 2024 - nature.com
An increased interest to expand three-dimensional chemical space for the design of new
materials and medicines has created a demand for isosteric replacement groups of …

Molecules Featuring the Azaheterocycle Moiety toward the Application of Flame-Retardant Polymers

S Lu, S Chen, L Luo, Y Yang, J Wang… - ACS Chemical Health …, 2023 - ACS Publications
Flame retardancy is a desirable property of polymer materials, and the molecular design of
novel flame-retardant structures considers three main aspects:(i) the chemical structure …

Selective Synthesis of Sulfonamides and Sulfenamides from Sodium Sulfinates and Amines

R Feng, ZY Li, YJ Liu, ZB Dong - The Journal of Organic …, 2024 - ACS Publications
An effective method was explored for the selective synthesis of sulfonamides and
sulfenamides using sodium sulfinates and amines as starting materials. This method offers …

The Modular Synthesis of Sulfondiimidoyl Fluorides and their Application to Sulfondiimidamide and Sulfondiimine Synthesis

M Ding, C Bell, MC Willis - Angewandte Chemie, 2024 - Wiley Online Library
A modular synthesis of sulfondiimidoyl fluorides—the double aza‐analogues of sulfonyl
fluorides—allowing variation of the carbon and both nitrogen‐substituents is reported. The …

Rapid aminations of functionalized aryl fluorosulfates in water

BH Lipshutz, K Dismuke Rodriguez… - Angewandte Chemie … - Wiley Online Library
Aryl fluorosulfates of varying complexities have been used in amination reactions in water
using a new Pd oxidative addition complex (OAC‐1) developed specifically to match the …

Switching to the non-PFAS-containing fluorosulfate leaving group, together with a Pd oxidative addition complex: rapid aminations of functionalized aromatics in water

K Iyer, KD Rodriguez, R Lammert, J Yirak, J Saunders… - 2024 - chemrxiv.org
Aryl fluorosulfates of varying complexities have been used in amination reactions in water
using a new Pd oxidative addition complex (OAC) developed specifically to match the needs …

Investigations of one-pot synthetic transformations mediated by sulfuryl fluoride and thionyl fluoride

TG Bolduc - 2023 - open.library.ubc.ca
The development of mild, selective, efficient, and economical chemical transformations is a
foundation of modern synthetic organic chemistry. These chemical processes may be …