Riding the metal wave: A review of the latest developments in metal-based anticancer agents
Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …
as candidates with great potential for cancer therapy. These agents are effective in a variety …
Copper complexes as anticancer agents targeting topoisomerases I and II
C Molinaro, A Martoriati, L Pelinski, K Cailliau - Cancers, 2020 - mdpi.com
Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …
chemotherapeutics used alone or in combination with other drugs. One small group of …
Anticancer potency of copper (II) complexes of thiosemicarbazones
NK Singh, AA Kumbhar, YR Pokharel… - Journal of Inorganic …, 2020 - Elsevier
Being a structural and catalytic cofactor in a number of biological pathways, copper
accumulates in tumors owing to selective permeability of the cancer cell membranes …
accumulates in tumors owing to selective permeability of the cancer cell membranes …
The coordination modes of (thio) semicarbazone copper (II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity
Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism
of action is often linked to their metal chelating ability. In this study, five (thio) …
of action is often linked to their metal chelating ability. In this study, five (thio) …
From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases
J Ceramella, A Mariconda, D Iacopetta… - Bioorganic & Medicinal …, 2020 - Elsevier
Cancer is a complex issue and, even though the prevention basics and therapy have been
implemented, it is still the second leading death cause worldwide. With the hope to discover …
implemented, it is still the second leading death cause worldwide. With the hope to discover …
Copper complexes as antitumor agents: In vitro and in vivo evidence
Copper is an essential element for most aerobic organisms, with an important function as a
structural and catalytic cofactor, and in consequence, it is implicated in several biological …
structural and catalytic cofactor, and in consequence, it is implicated in several biological …
Medicinal utility of thiosemicarbazones with special reference to mixed ligand and mixed metal complexes: A Review
Thiosemicarbazone complexes possess structural diversity and variable bonding patterns
and potential biological implications and ion sensing abilities. The ability of the transition …
and potential biological implications and ion sensing abilities. The ability of the transition …
Copper nanodrugs by atom transfer radical polymerization
P Chen, Z Song, X Yao, W Wang, L Teng… - Angewandte Chemie …, 2024 - Wiley Online Library
In this study, some copper catalysts used for atom transfer radical polymerization (ATRP)
were explored as efficient anti‐tumor agents. The aqueous solution of copper‐containing …
were explored as efficient anti‐tumor agents. The aqueous solution of copper‐containing …
Design, synthesis, cytotoxic screening and molecular docking studies of novel hybrid thiosemicarbazone derivatives as anticancer agents
FZ Mohammed, YW Rizzk, IM El Deen… - Chemistry & …, 2021 - Wiley Online Library
Thiosemicarbazones have been the focus of scientists owing to their broad clinical
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …
Clarifying the mechanism of copper (II) α-(N)-heterocyclic thiosemicarbazone complexes on DNA topoisomerase IIα and IIβ
JM Keck, JD Conner, JT Wilson, X Jiang… - Chemical Research …, 2019 - ACS Publications
Topoisomerase II is a nuclear enzyme involved in the maintenance of DNA and is an
effective anticancer drug target. However, several clinical topoisomerase II-targeted agents …
effective anticancer drug target. However, several clinical topoisomerase II-targeted agents …