Riding the metal wave: A review of the latest developments in metal-based anticancer agents

S Abdolmaleki, A Aliabadi, S Khaksar - Coordination Chemistry Reviews, 2024 - Elsevier
Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …

Copper complexes as anticancer agents targeting topoisomerases I and II

C Molinaro, A Martoriati, L Pelinski, K Cailliau - Cancers, 2020 - mdpi.com
Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …

Anticancer potency of copper (II) complexes of thiosemicarbazones

NK Singh, AA Kumbhar, YR Pokharel… - Journal of Inorganic …, 2020 - Elsevier
Being a structural and catalytic cofactor in a number of biological pathways, copper
accumulates in tumors owing to selective permeability of the cancer cell membranes …

The coordination modes of (thio) semicarbazone copper (II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity

V Pósa, B Hajdu, G Tóth, O Dömötör, CR Kowol… - Journal of Inorganic …, 2022 - Elsevier
Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism
of action is often linked to their metal chelating ability. In this study, five (thio) …

From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases

J Ceramella, A Mariconda, D Iacopetta… - Bioorganic & Medicinal …, 2020 - Elsevier
Cancer is a complex issue and, even though the prevention basics and therapy have been
implemented, it is still the second leading death cause worldwide. With the hope to discover …

Copper complexes as antitumor agents: In vitro and in vivo evidence

LM Balsa, EJ Baran, IE León - Current medicinal chemistry, 2023 - ingentaconnect.com
Copper is an essential element for most aerobic organisms, with an important function as a
structural and catalytic cofactor, and in consequence, it is implicated in several biological …

Medicinal utility of thiosemicarbazones with special reference to mixed ligand and mixed metal complexes: A Review

T Khan, S Raza, AJ Lawrence - Russian Journal of Coordination …, 2022 - Springer
Thiosemicarbazone complexes possess structural diversity and variable bonding patterns
and potential biological implications and ion sensing abilities. The ability of the transition …

Copper nanodrugs by atom transfer radical polymerization

P Chen, Z Song, X Yao, W Wang, L Teng… - Angewandte Chemie …, 2024 - Wiley Online Library
In this study, some copper catalysts used for atom transfer radical polymerization (ATRP)
were explored as efficient anti‐tumor agents. The aqueous solution of copper‐containing …

Design, synthesis, cytotoxic screening and molecular docking studies of novel hybrid thiosemicarbazone derivatives as anticancer agents

FZ Mohammed, YW Rizzk, IM El Deen… - Chemistry & …, 2021 - Wiley Online Library
Thiosemicarbazones have been the focus of scientists owing to their broad clinical
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …

Clarifying the mechanism of copper (II) α-(N)-heterocyclic thiosemicarbazone complexes on DNA topoisomerase IIα and IIβ

JM Keck, JD Conner, JT Wilson, X Jiang… - Chemical Research …, 2019 - ACS Publications
Topoisomerase II is a nuclear enzyme involved in the maintenance of DNA and is an
effective anticancer drug target. However, several clinical topoisomerase II-targeted agents …