Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment
Protein tyrosine kinases of the human epidermal growth factor receptor family, including
EGFR and HER2, have emerged as important therapeutic targets in non-small-cell lung …
EGFR and HER2, have emerged as important therapeutic targets in non-small-cell lung …
[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer
Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …
Molecular mechanisms of kidney injury and repair
S Rayego-Mateos, L Marquez-Expósito… - International journal of …, 2022 - mdpi.com
Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …
emphasizing the need to better understand the molecular mechanisms of damage and …
Isoliquiritigenin attenuates UUO-induced renal inflammation and fibrosis by inhibiting Mincle/Syk/NF-Kappa B signaling pathway
Y Liao, R Tan, J Li, T Liu, X Zhong, Y Yan… - Drug design …, 2020 - Taylor & Francis
Purpose Chronic kidney disease (CKD) is a global nephrotic syndrome characterized by
chronic inflammation, oxidative stress and fibrosis in the kidney. Isoliquiritigenin (ISL), a …
chronic inflammation, oxidative stress and fibrosis in the kidney. Isoliquiritigenin (ISL), a …
Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis
S Rayego-Mateos, S Campillo… - Clinical …, 2021 - portlandpress.com
Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …
Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
Z Wang, P Zhu, B Liao, H You, Y Cai - Journal of Orthopaedic Surgery and …, 2023 - Springer
Osteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the
joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial …
joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial …
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis
B Jaeger, JC Schupp, L Plappert, O Terwolbeck… - Nature …, 2022 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this
study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF …
study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF …
Mechanism of action of collagen and epidermal growth factor: A review on theory and research methods
MH Shahrajabian, W Sun - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
The most abundant protein found in mammals is collagen, and there are around 28 different
types of collagen found in the human body, but there are five types, namely, Type I, Type II …
types of collagen found in the human body, but there are five types, namely, Type I, Type II …