The epithelial–mesenchymal transition (EMT) is an essential event during cell development,
in which epithelial cells acquire mesenchymal fibroblast-like features including reduced …

The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular
components in tissues. In addition to functioning as a structural scaffold for cellular …

Wound healing occurs as a response to disruption of the epidermis and dermis. It is an
intricate and well-orchestrated response with the goal to restore skin integrity and function …

Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular
matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans …

Significance: When a cutaneous injury occurs, the wound heals via a dynamic series of
physiological events, including coagulation, granulation tissue formation, re …

Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with
excessive deposition of extracellular matrix and connective tissue at the site of injury. In this …

Skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix
deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as …

Substantial progress has been achieved over the last few decades in the development of
skin equivalents to model the skin as an organ. However, their static culture still limits the …

Hypertrophic scars (HTS) and keloids are challenging problems. Their pathogenesis results
from an overproduction of fibroblasts and excessive deposition of collagen. Studies suggest …

Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that
manifest when the cicatrix fails to properly heal. They result from pathologic wound healing …