Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome.
Understanding of the complex pathways involved in lung injury pathogenesis, resolution …

Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …

Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

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Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Background Effective targeted therapy for sepsis requires an understanding of the
heterogeneity in the individual host response to infection. We investigated this heterogeneity …

Community-acquired pneumonia causes great mortality and morbidity and high costs
worldwide. Empirical selection of antibiotic treatment is the cornerstone of management of …

Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

Pneumonia is the leading infectious cause of mortality worldwide and one of the most
common lower respiratory tract infections that is contributing significantly to the burden of …