A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

Protein structure underlies essential biological processes and provides a blueprint for
molecular mimicry that drives drug discovery. Although small molecules represent the lion's …

Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms. Although AMPs have been essentially studied and developed as potential …

During apoptotic cell death, cellular stress signals converge at the mitochondria to induce
mitochondrial outer-membrane permeabilization (MOMP) through B cell lymphoma-2 (BCL …

Peptides, defined as polymers of less than 50 amino acids with a molecular weight of less
than 10 kDa, represent a fast-growing class of new therapeutics which has unique …

Peptides and peptide-conjugates, comprising natural and synthetic building blocks, are an
increasingly popular class of biomaterials. Self-assembled nanostructures based on …

Hydrocarbon-stapled peptides are a class of bioactive alpha-helical ligands developed to
dissect and target protein interactions. While there is consensus that stapled peptides can …