Sex is one of several factors influencing pharmacological responses, but research on its
effects on pharmacokinetics and pharmacodynamics, although emerging remarkably …

Background Laparoscopic cholecystectomy frequently results in significant immediate
postoperative pain. A new pain monitor, analgesic nociception index (ANI®), based on heart …

Objectives: The effect of dexamethasone on analgesic consumption has not been
adequately studied. The aim of this review was to investigate recent literature regarding the …

Characterizing the gut microbiota in terms of their capacity to interfere with drug metabolism
is necessary to achieve drug efficacy and safety. Although examples of drug-microbiome …

Background: The pain pattern after laparoscopic cholecystectomy (LC) is complex and
distinct from postoperative pain after other laparoscopic procedures, suggesting that …

Introduction: Phytocannabinoids have emerged as a potential alternative treatment option
for individuals experiencing persistent pain. However, evidence-based research regarding …

Purpose Postoperative nausea and vomiting (PONV) are main issues after same-day
surgery. This study aimed to retrospectively evaluate the electronic medical records of …

Background Pain is common in older patients and management guidelines rarely consider
the effect of multiple comorbidities and concurrent medications on analgesic selection …

Background Although reports suggest that pain and postoperative nausea and vomiting
(PONV) may be more frequent in women, the evidence is inconsistent. The objective of this …

Introduction In the current opioid crisis, bariatric surgical patients are at increased risk of
harms related to postoperative opioid overprescribing. This study aimed to assess the extent …