Mouse models of human cancer have played a vital role in understanding tumorigenesis
and answering experimental questions that other systems cannot address. Advances …

The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor
tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3 …

Nowadays, the usage of nanoparticles in various fields such as drug delivery, attracts the
attention of many researchers in the treatment of cancers. Graphene oxide (GO) is one of the …

Breast cancer is a disease in which cancer cells form in the tissues of the breast. The
present study aimed to explore the effect of the flavonoid compound quercetin on the growth …

Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-
renewal as well as in tumor development. However, the role of Notch signaling in breast …

Activation of the ErbB family of receptor tyrosine kinases via cognate Epidermal Growth
Factor (EGF)-like peptide ligands constitutes a major group of related signaling pathways …

Angiogenesis affects both wound healing and malignant cell growth through nutrients and
oxygen. Vascular endothelial growth factor (VEGF) is the most important element involved in …

Despite advancements in therapies developed for the treatment of cancer, patient prognosis
and mortality rates have improved minimally, and metastasis remains the primary cause of …

Background There has been an extensive range of incidence and mortality of breast cancer
(BC), and the comprehensively available treatments for BC have not been completely …

Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …