Flavonoid production: current trends in plant metabolic engineering and de novo microbial production

H Tariq, S Asif, A Andleeb, C Hano, BH Abbasi - Metabolites, 2023 - mdpi.com
Flavonoids are secondary metabolites that represent a heterogeneous family of plant
polyphenolic compounds. Recent research has determined that the health benefits of fruits …

The “beauty in the beast”—the multiple uses of Priestia megaterium in biotechnology

R Biedendieck, T Knuuti, SJ Moore, D Jahn - Applied microbiology and …, 2021 - Springer
Over 30 years, the Gram-positive bacterium Priestia megaterium (previously known as
Bacillus megaterium) was systematically developed for biotechnological applications …

Hemoprotein catalyzed oxygenations: P450s, UPOs, and progress toward scalable reactions

G Grogan - JACS Au, 2021 - ACS Publications
The selective oxygenation of nonactivated carbon atoms is an ongoing synthetic challenge,
and biocatalysts, particularly hemoprotein oxygenases, continue to be investigated for their …

Production of plant natural products through engineered Yarrowia lipolytica

A Muhammad, X Feng, A Rasool, W Sun, C Li - Biotechnology Advances, 2020 - Elsevier
Plant natural products have broad applications in the pharmaceutical, food, cosmetics and
flavor industries. However, the current manufacturing methods for plant natural products …

Efficient Biosynthesis of (2S)-Naringenin from p-Coumaric Acid in Saccharomyces cerevisiae

S Gao, Y Lyu, W Zeng, G Du, J Zhou… - Journal of agricultural …, 2019 - ACS Publications
(2 S)-Naringenin, a (2 S)-flavanone, is widely used in the food, chemical, and
pharmaceutical industries because of its diverse physiological activities. The production of …

Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models

JMPF de Oliveira, C Santos, E Fernandes - Phytomedicine, 2020 - Elsevier
Background The ability of cancer cells to divide without restriction and to escape
programmed cell death is a feature of the proliferative state. Citrus flavanones are flavonoids …

Biological valorization of lignin to flavonoids

HN Lan, RY Liu, ZH Liu, X Li, BZ Li, YJ Yuan - Biotechnology Advances, 2023 - Elsevier
Lignin is the most affluent natural aromatic biopolymer on the earth, which is the promising
renewable source for valuable products to promote the sustainability of biorefinery …

Whole-cell biocatalysis using cytochrome P450 monooxygenases for biotransformation of sustainable bioresources (fatty acids, fatty alkanes, and aromatic amino …

HA Park, G Park, W Jeon, JO Ahn, YH Yang… - Biotechnology …, 2020 - Elsevier
Cytochrome P450s (CYPs) are heme-thiolated enzymes that catalyze the oxidation of C
single bond H bonds in a regio and stereoselective manner. Activation of the non-activated …

Systematically Engineered Fatty Acid Catabolite Pathway for the Production of (2S)-Naringenin in Saccharomyces cerevisiae

Q Zhang, S Yu, Y Lyu, W Zeng, J Zhou - ACS Synthetic Biology, 2021 - ACS Publications
The (2 S)-naringenin is an important natural flavonoid with several bioactive effects on
human health. It is also a key precursor in the biosynthesis of other high value compounds …

A rapid and versatile tool for genomic engineering in Lactococcus lactis

T Guo, Y Xin, Y Zhang, X Gu, J Kong - Microbial Cell Factories, 2019 - Springer
Background Lactococcus lactis is one of the most extensively characterized lactic acid
bacteria, from physiological traits to industrial exploitation. Since last decade, L. lactis has …