Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist
Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated …

Abstract Triple-Negative Breast Cancer (TNBC) presents a significant challenge in oncology
due to its aggressive behavior and limited therapeutic options. This review explores the …

We report a self-consistent method to translate amino acid sequences into audible sound,
use the representation in the musical space to train a neural network, and then apply it to …

Introduction: Hydroxylation is one of the most important post-translational modifications
(PTM) in cellular functions and is linked to various diseases. The addition of one of the …

We report the use of a deep learning model to design de novo proteins, based on the
interplay of elementary building blocks via hierarchical patterns. The deep neural network …

Plant cytochrome P450s play key roles in the diversification and functional modification of
plant natural products. Although over 200,000 plant P450 gene sequences have been …

Apart from the canonical fingers, palm and thumb domains, the RNA dependent RNA
polymerases (RdRp) from the viral order Nidovirales possess two additional domains. Of …

VHH, ie, VH domains of camelid single-chain antibodies, are very promising therapeutic
agents due to their significant physicochemical advantages compared to classical …

Our protein block (PB) sequence database PDB-2-PBv1. 0 provides PB sequences and
dihedral angles for 74,297 protein structures comprising of 103,252 protein chains of Protein …

The development of rational techniques to discover new mechanically relevant proteins for
use in variety of applications ranging from mechanics, agriculture to biotechnology remains …