Impaired mitochondrial function and aberrant neuronal network activity are believed to be
early events in the pathogenesis of Alzheimer9s disease (AD), but how mitochondrial …

Molecular subtyping of cancer offers tremendous promise for the optimization of a precision
oncology approach to anticancer therapy. Recent advances in pancreatic cancer research …

Multidrug resistance (MDR) hinders treatment efficacy in cancer therapy. One typical
mechanism contributing to MDR is the overexpression of permeability-glycoprotein (P-gp) …

BHLHE40 is a transcription factor, whose role in colorectal cancer has remained elusive. We
demonstrate that the BHLHE40 gene is upregulated in colorectal tumors. Transcription of …

Aging is the major risk factor for Alzheimer's disease (AD). Mitochondrial dysfunction and
neuronal network hyperexcitability are two age-related alterations implicated in AD …

Abstract Background Dysfunctional processes in Alzheimer's disease and other
neurodegenerative diseases lead to neural degeneration in the central and peripheral …

Background Neonatal hyperoxia exposure is associated with brain injury and poor
neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent …

Abstract Background Patient and Public Involvement (PPI) in health research is gaining
increased attention and acceptance worldwide. Reliable measurements are crucial to …

Generation of desired cell types by cell conversion remains a challenge. In particular,
derivation of novel cell subtypes identified by single-cell technologies will open up new …

Mouse knockouts of Cntnap2 show altered neurodevelopmental behavior, deficits in striatal
GABAergic signaling, and a genome-wide disruption of an environmentally sensitive DNA …