Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

Current understanding on the mechanisms of brain injury and neurodegeneration highlights
an appreciation of multicellular interactions within the neurovascular unit (NVU), which …

The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a
multifunctional protein with activities far beyond its well-known role in the unfolded protein …

Despite decades of research, current therapeutic interventions for Parkinson's disease (PD)
are insufficient as they fail to modify disease progression by ameliorating the underlying …

Healthy aging requires the coordination of numerous stress signaling pathways that
converge on the protein homeostasis network. The integrated stress response (ISR) is …

Parkinson's disease (PD) is a multifactorial age-related movement disorder in which defects
of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded …

Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's
disease (AD). Disease progression is associated with a reduction in glucose transporters in …

Parkinson's disease (PD) is a chronic, progressive movement disorder of adults and the
second most common neurodegenerative disease after Alzheimer's disease …

Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …

Alpha-synuclein (aSyn) was identified as the main component of inclusions that define
synucleinopathies more than 20 years ago. Since then, aSyn has been extensively studied …