Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

The cell cycle is a complex and strictly controlled process, consisting of different phases.
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The …

Shape memory sponges are very promising in stopping the bleeding from noncompressible
and narrow entrance wounds. However, few shape memory sponges have fast degradable …

Over the past 20 years, various identifiers of cellular senescence have been used to quantify
the abundance of these cells in different tissues. These include classic markers such as p16 …

The PIDDosome is a multiprotein complex that drives activation of caspase-2, an
endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell …

After extensive proliferation during development, the adult skeletal muscle cells remain
outside the cell cycle, either as post-mitotic myofibers or as quiescent muscle stem cells …

Skeletal muscle comprises approximately 40% of the total body mass. Preserving muscle
health and function is essential for the entire body in order to counteract chronic diseases …

Inducing cardiomyocyte proliferation is a hopeful approach for cardiac regeneration
following myocardial infarction. Previous studies have shown that p21 inhibits the …

ZBED6 (zinc finger BED domain containing protein 6) is a transcription factor unique to
placental mammals and its interaction with the IGF2 (insulin-like growth factor 2) locus plays …

Sirt2 regulates various biological processes by deacetylating target genes. Despite roles in
regulating proliferation, cell cycle, and glucose metabolism, which are closely associated …