Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

JLB Simões, HF Basso, GC Kosvoski, J Gavioli… - International …, 2021 - Elsevier
The etiological agent of coronavirus disease (COVID-19) is the new member of the
Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV …

[HTML][HTML] Curcumin inhibits adenosine deaminase and arginase activities in cadmium-induced renal toxicity in rat kidney

AJ Akinyemi, N Onyebueke, OA Faboya… - journal of food and drug …, 2017 - Elsevier
In this study, the effect of enzymes involved in degradation of renal adenosine and l-arginine
was investigated in rats exposed to cadmium (Cd) and treated with curcumin, the principal …

[HTML][HTML] Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats

MFV Castro, N Stefanello, CE Assmann, J Baldissarelli… - Life Sciences, 2021 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder characterized by a chronic hyperglycemia
state, increased oxidative stress parameters, and inflammatory processes. Aims To evaluate …

Alterations in the cholinesterase and adenosine deaminase activities and inflammation biomarker levels in patients with multiple sclerosis

CRN Polachini, RM Spanevello, EA Casali, D Zanini… - Neuroscience, 2014 - Elsevier
Multiple sclerosis (MS) is one of the main chronic inflammatory diseases of the CNS that
cause functional disability in young adults. It has unknown etiology characterized by the …

Tannic acid attenuates peripheral and brain changes in a preclinical rat model of glioblastoma by modulating oxidative stress and purinergic signaling

NP Bona, MSP Soares, NS Pedra, L Spohr… - Neurochemical …, 2022 - Springer
Glioblastoma (GB) is a highly aggressive and invasive brain tumor; its treatment remains
palliative. Tannic acid (TA) is a polyphenol widely found in foods and possesses antitumor …

Ectoenzymes and cholinesterase activity and biomarkers of oxidative stress in patients with lung cancer

D Zanini, R Schmatz, LP Pelinson, VC Pimentel… - Molecular and Cellular …, 2013 - Springer
We aimed to examine the nucleoside triphosphate diphosphohydrolases (NTPDase) in
lymphocytes; adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in serum; and …

The signaling effects of ATP on melanoma-like skin cancer

A Mânica, BSR Bonadiman, AM Cardoso, A Paiz… - Cellular …, 2019 - Elsevier
Melanoma is a type of skin cancer originated by the malignant transformation of
melanocytes. Increasing incidence and mortality require efforts focused on studies and …

Swimming training prevents alterations in acetylcholinesterase and butyrylcholinesterase activities in hypertensive rats

AM Cardoso, FH Abdalla, MD Bagatini… - American journal of …, 2014 - academic.oup.com
BACKGROUND Cholinergic enzyme activities are altered in hypertension, reflecting a low-
grade inflammation. Regular physical exercise exerts anti-inflammatory effects and has …

High levels of extracellular ATP lead to chronic inflammatory response in melanoma patients

A Manica, AM Da Silva, AM Cardoso… - Journal of cellular …, 2018 - Wiley Online Library
Skin cancer represents a serious public health problem and melanoma is considered the
most significant due to its high metastasis capacity. Evasion mechanisms are the main …

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide‐induced sepsis in rats

VV Miron, NB Bottari, CE Assmann… - Journal of Cellular …, 2019 - Wiley Online Library
Sepsis is a generalized infection that involves alterations in inflammatory parameters,
oxidant status, and purinergic signaling in many tissues. Physical exercise has emerged as …