T‐cell exhaustion in HIV infection
C Fenwick, V Joo, P Jacquier, A Noto… - Immunological …, 2019 - Wiley Online Library
The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
Pathophysiology of CD4+ T-cell depletion in HIV-1 and HIV-2 infections
KK Vidya Vijayan, KP Karthigeyan, SP Tripathi… - Frontiers in …, 2017 - frontiersin.org
The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity …
Soluble markers of inflammation and coagulation but not T-cell activation predict non–AIDS-defining morbid events during suppressive antiretroviral treatment
AR Tenorio, Y Zheng, RJ Bosch… - The Journal of …, 2014 - academic.oup.com
Background. Defining the association of non–AIDS-defining events with inflammation and
immune activation among human immunodeficiency virus (HIV)–infected persons with …
immune activation among human immunodeficiency virus (HIV)–infected persons with …
CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier,
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
translocation of immunostimulatory microbial products, and chronic systemic inflammation …
Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
PW Hunt, E Sinclair, B Rodriguez… - The Journal of …, 2014 - academic.oup.com
Background. While inflammation predicts mortality in treated human immunodeficiency virus
(HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell …
(HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell …
Plasma levels of soluble CD14 independently predict mortality in HIV infection
NG Sandler, H Wand, A Roque, M Law… - Journal of Infectious …, 2011 - academic.oup.com
Background. Chronic human immunodeficiency virus (HIV) infection is associated with
intestinal permeability and microbial translocation that contributes to systemic immune …
intestinal permeability and microbial translocation that contributes to systemic immune …
HIV‐associated chronic immune activation
M Paiardini, M Müller‐Trutwin - Immunological reviews, 2013 - Wiley Online Library
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
Microbial translocation in the pathogenesis of HIV infection and AIDS
G Marchetti, C Tincati, G Silvestri - Clinical microbiology reviews, 2013 - Am Soc Microbiol
In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …
Is HIV a model of accelerated or accentuated aging?
Background. Antiretroviral therapy has reduced the incidence of adverse events and early
mortality in HIV-infected persons. Despite these benefits, important comorbidities that …
mortality in HIV-infected persons. Despite these benefits, important comorbidities that …