Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Technological developments, especially in mass spectrometry and bioinformatics, have
revealed that living cells contain thousands rather than dozens of different lipids [for …

G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …

Abstract Lysophosphatidic acid receptor 1 (LPA1) is one of the six G protein-coupled
receptors activated by the bioactive lipid, lysophosphatidic acid (LPA). LPA1 is a drug target …

Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Liver fibrosis resulting from chronic liver injury are major causes of morbidity and mortality
worldwide. Among causes of hepatic fibrosis, viral infection is most common (hepatitis B and …

The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs
unusually early in tumour evolution. Unlike most solid tumours, thickness rather than …

Objective Preclinical studies suggest a role for lysophosphatidic acid (LPA) in the
pathogenesis of systemic sclerosis (SS c). We undertook this study to assess SAR 100842, a …

Key points Lysophosphatidic acid (LPA) is an itch mediator, but not a pain mediator by a
cheek injection model. Dorsal root ganglion neurons directly respond to LPA depending on …