Genomic characterization of viral integration sites in HPV‐related cancers

C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …

A census of pathway maps in cancer systems biology

BM Kuenzi, T Ideker - Nature Reviews Cancer, 2020 - nature.com
A key goal of cancer systems biology is to use big data to elucidate the molecular networks
by which cancer develops. However, to date there has been no systematic evaluation of how …

[HTML][HTML] The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis

L Mirabello, MA Clarke, CW Nelson, M Dean… - 2018 - mdpi.com
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …

[HTML][HTML] Cervical cancer heterogeneity: a constant battle against viruses and drugs

Q Sun, L Wang, C Zhang, Z Hong, Z Han - Biomarker Research, 2022 - Springer
Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the
most promising malignancy to be eliminated. However, the ever-changing virus subtypes …

Human papillomavirus in oropharyngeal cancer: The changing face of a disease

J Mallen-St Clair, M Alani, MB Wang… - Biochimica et Biophysica …, 2016 - Elsevier
The last decade has brought about an unexpected rise in oropharyngeal squamous cell
carcinoma (OPSCC) primarily in white males from the ages of 40–55 years, with limited …

[HTML][HTML] Increased expression of HPV-E7 oncoprotein correlates with a reduced level of pRb proteins via high viral load in cervical cancer

BA Mir, A Ahmad, N Farooq, MV Priya, AH Siddiqui… - Scientific Reports, 2023 - nature.com
Human Papillomavirus (HPV) is the most common cause of sexually transmitted diseases
and causes a wide range of pathologies including cervical carcinoma. Integration of the HR …

[HTML][HTML] Somatic host cell alterations in HPV carcinogenesis

TR Litwin, MA Clarke, M Dean, N Wentzensen - Viruses, 2017 - mdpi.com
High-risk human papilloma virus (HPV) infections cause cancers in different organ sites,
most commonly cervical and head and neck cancers. While carcinogenesis is initiated by …

Molecular classification of epithelial ovarian cancer based on methylation profiling: evidence for survival heterogeneity

C Bodelon, JK Killian, JN Sampson, WF Anderson… - Clinical Cancer …, 2019 - AACR
Purpose: Ovarian cancer is a heterogeneous disease that can be divided into multiple
subtypes with variable etiology, pathogenesis, and prognosis. We analyzed DNA …

Molecular tests potentially improving HPV screening and genotyping for cervical cancer prevention

A Gradíssimo, RD Burk - Expert Review of Molecular Diagnostics, 2017 - Taylor & Francis
ABSTRACT Introduction: Human papillomavirus (HPV)-related cancers can be averted by
type-specific vaccination (primary prevention) and/or through detection and ablation of …

[HTML][HTML] Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs

A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …