Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson's Disease Animal Model

LD Bernal-Conde, V Peña-Martínez, CA Morato-Torres… - Life, 2024 - mdpi.com
Parkinson's disease (PD) caused by SNCA gene triplication (3X SNCA) leads to early onset,
rapid progression, and often dementia. Understanding the impact of 3X SNCA and its …

Human stem cell transplantation for Parkinson's disease: A systematic review of in situ survival and maturation of progenitors derived from human embryonic or …

G Comini, E Dowd - bioRxiv, 2024 - biorxiv.org
Stem cell-based brain repair is a promising emergent therapy for Parkinson's which is based
on years of foundational research using human fetal donors as a cell source. Unlike current …