Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

The co-morbidity between smoking and mood disorders is striking. Preclinical and clinical
studies of nicotinic effects on mood, anxiety, aggression, and related behaviors, such as …

The addiction‐relevant molecular, cellular, and behavioral actions of nicotine are derived
from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the …

Cigarette smoking is the largest preventable risk factor for morbidity and mortality in
developed countries. Dramatic changes in the prevalence of cigarette smoking in the …

In humans, nicotine has been shown to improve attention in both normal and impaired
individuals. Observations in rats reflect some, but not all aspects of the nicotine-induced …

We reanalyze data from the 1981 mailed questionnaire survey of the Australian twin register,
to test for a genetic effect on smoking persistence (whether or not a smoker quits smoking) …

The in vivo and in vitro effects of A1 on the cholinergic system of rat brain were studied. The
amount of A1 accumulated after the chronic, intraperitoneal administration of aluminum …

Activation of protein kinase C (PKC) via neurotransmitter coupling processes has been
associated with long-term potentiation (LTP) or classical conditioning, but whether natural …