Leptin acts on leptin receptor (LepRb)-expressing neurons throughout the brain, but the
roles for many populations of LepRb neurons in modulating energy balance and behavior …

Few effective measures exist to combat the worldwide obesity epidemic, and the
identification of potential therapeutic targets requires a deeper understanding of the …

Objective Obesity is one of the primary healthcare challenges of the 21st century. Signals
relaying information regarding energy needs are integrated within the brain to influence …

Leptin acts via its receptor (LepRb) on specific CNS neurons to signal the adequacy of long-
term energy stores, thereby permitting the expenditure of resources on energy-intensive …

Leptin, the adipose-derived hormonal signal of body energy stores, acts via the leptin
receptor (LepRb) on neurons in multiple brain regions. We previously identified LepRb …

Leukocyte and platelet accumulation at sites of cerebral ischemia exacerbate cerebral
damage. The ectoenzyme CD39 on the plasmalemma of endothelial cells metabolizes ADP …

The hypothalamus plays a crucial role in the modulation of social behavior by encoding
internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators …

The central mechanism by which neurotensin (Nts) potentiates weight loss has remained
elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral …

Leptin action in the brain signals the repletion of adipose energy stores, suppressing
feeding and permitting energy expenditure on a variety of processes, including reproduction …

A variety of data suggest that estrogen action on kisspeptin (Kiss1)-containing arcuate
nucleus neurons (which coexpress Kiss1, neurokinin B (the product of Tac2) and dynorphin …