Treating prostate cancer by antibody–drug conjugates

M Rosellini, M Santoni, V Mollica, A Rizzo… - International journal of …, 2021 - mdpi.com
Prostate cancer is the most frequent malignancy in the worldwide male population; it is also
one of the most common among all the leading cancer-related death causes. In the last two …

STEAP1–4 (six-transmembrane epithelial antigen of the prostate 1–4) and their clinical implications for prostate cancer

M Xu, L Evans, CL Bizzaro, F Quaglia, CE Verrillo, L Li… - Cancers, 2022 - mdpi.com
Simple Summary Despite recent therapeutic advances in the treatment of prostate cancer,
metastatic castration-resistant prostate cancer continues to cause significant morbidity and …

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy

V Bhatia, NV Kamat, TE Pariva, LT Wu, A Tsao… - Nature …, 2023 - nature.com
Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for
therapeutic targeting in prostate cancer. Here, we report broad expression of STEAP1 …

AMG 509 (xaluritamig), an anti-STEAP1 XmAb 2+ 1 T-cell redirecting immune therapy with avidity-dependent activity against prostate cancer

O Nolan-Stevaux, C Li, L Liang, J Zhan, J Estrada… - Cancer Discovery, 2024 - AACR
The tumor-associated antigen STEAP1 is a potential therapeutic target that is expressed in
most prostate tumors and at increased levels in metastatic castration-resistant prostate …

The tumor suppressive roles and prognostic values of STEAP family members in breast cancer

HT Wu, WJ Chen, Y Xu, JX Shen… - BioMed research …, 2020 - Wiley Online Library
Objective. To investigate the expression patterns and prognostic values of STEAP family
members in the occurrence and development of breast cancer. Materials and Methods. The …

Regulatory roles of six-transmembrane epithelial antigen of the prostate family members in the occurrence and development of malignant tumors

WJ Chen, HT Wu, CL Li, YK Lin, ZX Fang… - Frontiers in Cell and …, 2021 - frontiersin.org
The human six-transmembrane epithelial antigen of the prostate (STEAP) proteins, which
include STEAP1–4 and atypical STEAP1B, contain six transmembrane domains and are …

The Prognostic Value and Immunological Role of STEAP1 in Pan‐Cancer: A Result of Data‐Based Analysis

C Zhao, K Xiong, Z Ji, F Liu, X Li - Oxidative Medicine and …, 2022 - Wiley Online Library
Purpose. This study is aimed at systematically analyzing the expression, function, and
prognostic value of six transmembrane epithelial antigen of the prostate 1 (STEAP1) in …

[HTML][HTML] Development of a novel electrochemical biosensor based on plastic antibodies for detection of STEAP1 biomarker in cancer

M Carvalho, RM Gomes, SM Rocha… - …, 2023 - Elsevier
STEAP1 is a cell surface protein of the STEAP family whose main function focuses on
intercellular communication and cell growth. STEAP1 is considered a promising putative …

Evaluation of the prognostic value of STEAP1 in lung adenocarcinoma and insights into its potential molecular pathways via bioinformatic analysis

Q Guo, X Ke, Z Liu, WL Gao, SX Fang, C Chen… - Frontiers in …, 2020 - frontiersin.org
Background Upregulation of the six-transmembrane epithelial antigen of prostate-1
(STEAP1) is closely associated with prognosis of numerous malignant cancers. However, its …

The usefulness of STEAP proteins in prostate cancer clinical practice

S Rocha, J Barroca-Ferreira, L Passarinha… - Exon …, 2021 - exonpublications.com
Prostate cancer is a multifactorial disease and the second most common cancer diagnosed
in men worldwide. The six transmembrane epithelial antigen of prostate (STEAP) proteins …