Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

ABSTRACT Macroautophagy (hereafter “autophagy”) is a membrane-mediated biological
process that involves engulfing and delivering cytoplasmic components to lysosomes for …

The transcription factor NRF2 coordinates the expression of a vast array of cytoprotective
and metabolic genes in response to various stress inputs to restore cellular homeostasis …

Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …

Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

Simple Summary Nuclear factor erythroid-derived 2-like 2 (encoded by the Nfe2l2 gene;
NRF2) is a transcription factor that regulates a variety of cytoprotective genes, including …

Introduction Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation
where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus …

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …