The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Animal models of acute and chronic pancreatitis have been created to examine mechanisms
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …

Acute pancreatitis is an acute inflammatory process of the pancreas that frequently involves
peripancreatic tissues and at times remote organ systems. The severity of the disease varies …

Autodigestion of the pancreas by its own prematurely activated digestive proteases is
thought to be an important event in the onset of acute pancreatitis. The mechanism …

Background: The common channel theory suggests that bile reflux, through a common
biliopancreatic channel, triggers acute pancreatitis. In the present study, this controversial …

Background Acute pancreatitis has long been considered a disorder of pancreatic self-
digestion, in which intracellular activation of digestive proteases induces tissue injury …

Supramaximal stimulation of the pancreas with the CCK analog caerulein causes acute
edematous pancreatitis. In this model, active trypsin can be detected in the pancreas shortly …

The underlying mechanisms involved in the pathogenesis of acute pancreatitis are ill
understood. The mortality rate of this disease has not significantly improved over the past …

Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a
substantial morbidity and mortality. Currently there is no specific treatment for the disease …

Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …