Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

In the last decades, the communication between the Endoplasmic reticulum (ER) and
mitochondria has obtained great attention: mitochondria-associated membranes (MAMs) …

Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having
varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic coupling
structures between mitochondria and the endoplasmic reticulum (ER). As a new subcellular …