Background Exposure to acute prolonged sitting can result in vascular dysfunction,
particularly within the legs. This vascular dysfunction, assessed using flow-mediated dilation …

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
western world. In the last three decades, fluid dynamics investigations have been an …

Endothelial dysfunction is a pathological status of the vascular system, which can be broadly
defined as an imbalance between endothelium-dependent vasoconstriction and …

Sedentary behavior, particularly sitting, is ubiquitous in many contemporary societies. This is
a major societal concern considering the evidence for a strong association between sitting …

Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its
nuclear action, whereas plasma membrane-located ERα accelerates endothelial healing …

Caffeine consumption has been receiving increased interest from both the medical and lay
press, especially given the increased amounts now available in energy products. Acute …

Objective. Premature coronary heart disease (CHD) significantly affects morbidity and
mortality in systemic lupus erythematosus (SLE). Several studies have detected factors …

Exposure to prolonged sitting increases blood pooling and the risk of lower-extremity
vascular arterial and venous complications, including deep vein thrombosis. Compression …

Currently, the physiological mechanisms that allow elite level climbers to maintain intense
isometric contractions for prolonged periods of time are unknown. Furthermore, it is unclear …

Objective Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity.
Previous studies have shown that exercise significantly restores circulating EPC levels in …