Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Angiogenesis after acute myocardial infarction
X Wu, MR Reboll, M Korf-Klingebiel… - Cardiovascular …, 2021 - academic.oup.com
Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction
High levels of lactate are positively associated with the prognosis and mortality in patients
with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in …
with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in …
[HTML][HTML] Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Endothelial cells play a critical role in the adaptation of tissues to injury. Tissue ischemia
induced by infarction leads to profound changes in endothelial cell functions and can induce …
induced by infarction leads to profound changes in endothelial cell functions and can induce …
[HTML][HTML] Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation
V Sorokin, K Vickneson, T Kofidis, CC Woo… - Frontiers in …, 2020 - frontiersin.org
The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …
approaches to address its high morbidity and mortality. To date, over 17 million …
[HTML][HTML] Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …
[HTML][HTML] Inflammation and oxidative stress in diabetic kidney disease: the targets for SGLT2 inhibitors and GLP-1 receptor agonists
A Winiarska, M Knysak, K Nabrdalik… - International Journal of …, 2021 - mdpi.com
The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …
[HTML][HTML] Endothelial to mesenchymal transition in health and disease
Y Xu, JC Kovacic - Annual Review of Physiology, 2023 - annualreviews.org
The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …
Endothelial-mesenchymal transition in cardiovascular disease
Z Alvandi, J Bischoff - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …
Endothelial function in cardiovascular medicine: a consensus paper of the European society of cardiology working groups on atherosclerosis and vascular biology …
Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …