Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-
ancestry genetic research of RA promises to improve power to detect genetic signals, fine …

Traditionally, chemokine immunobiology has focused on chemotaxis and the positioning of
cells at sites of inflammation and within lymphoid organs. More recently, however, regulation …

Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of
germinal center (GC) responses that together facilitate long-term humoral immunity …

Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic
lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs …

Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and
high-affinity B cell antigen receptors (BCRs) for pathogen clearance. Increased receptor …

The germinal center (GC) reaction plays an important role in generating humoral immunity
and is believed to give rise to most B-cell lymphomas. GC entry and exit are tightly regulated …

Chemokine-dependent localization of specific B cell subsets within the immune
microarchitecture is essential to ensure successful cognate interactions. Although cognate …

Gut-derived antigens trigger immunoglobulin A (IgA) immune responses that are initiated by
cognate B cells in Peyer's patches (PPs). These cells colonize the subepithelial domes …

Background: HIV infection dysregulates the B cell compartment, affecting memory B cell
formation and the antibody response to infection and vaccination. Understanding the B cell …

Systemic lupus erythematosus (SLE) is a highly variable autoimmune disease that can
involve severe organ-threatening symptoms, such as lupus nephritis. Certain drugs, such as …