The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

The family of cytokines signalling through the common receptor subunit gp130 comprises
interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor …

To study the cis-and trans-acting factors that mediate programmed death 1 (PD-1) signaling
in primary human CD4 T cells, we constructed a chimeric molecule consisting of the murine …

Programmed death‐1 (PD‐1) is a cell surface molecule that regulates the adaptive immune
response. Engagement of PD‐1 by its ligands PD‐L1 or PD‐L2 transduces a signal that …

The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 Å resolution, shows how
its catalytic activity is regulated by its two SH2 domains. In the absence of a tyrosine …

We have investigated the regulation of protein tyrosine phosphatases (PTPs) by reactive
oxygen species (ROS) in a cellular environment. We demonstrate that multiple PTPs were …

Most anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung tumors initially
respond to small-molecule ALK inhibitors, but drug resistance often develops,,,. Of tumors …

Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …

Abstract Interleukin (IL)-6 is a pleiotropic cytokine that not only affects the immune system,
but also acts in other biological systems and many physiological events in various organs. In …

The propagation of pluripotent mouse embryonic stem (ES) cells depends on signals
transduced through the cytokine receptor subunit gp130. Signalling molecules activated …