TEER measurement techniques for in vitro barrier model systems

B Srinivasan, AR Kolli, MB Esch… - Journal of …, 2015 - journals.sagepub.com
Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …

[HTML][HTML] The past, present and future of intestinal in vitro cell systems for drug absorption studies

S Youhanna, VM Lauschke - Journal of pharmaceutical sciences, 2021 - Elsevier
The intestinal epithelium acts as a selective barrier for the absorption of water, nutrients and
orally administered drugs. To evaluate the gastrointestinal permeability of a candidate …

Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs

F Antunes, F Andrade, F Araújo, D Ferreira… - European Journal of …, 2013 - Elsevier
In vitro cell culture models for studying oral drug absorption during early stages of drug
development have become a useful tool in drug discovery and development, with respect to …

Cell-based in vitro models for predicting drug permeability

B Sarmento, F Andrade, SB Silva… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: In vitro cell models have been used to predict drug permeation in early stages
of drug development, since they represent an easy and reproducible method, allowing the …

Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives

S Youhanna, AM Kemas, L Preiss, Y Zhou… - Pharmacological …, 2022 - ASPET
The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

Transport, metabolism and remedial potential of functional food extracts (FFEs) in Caco-2 cells monolayer: A review

M Iftikhar, A Iftikhar, H Zhang, L Gong… - Food Research …, 2020 - Elsevier
Caco-2, a human intestinal carcinoma cell line, has been used to test the absorption and
transport mechanism of functional foods and drugs across the intestinal epithelium in order …

In vitro and ex vivo modeling of enteric bacterial infections

N Taebnia, U Römling, VM Lauschke - Gut Microbes, 2023 - Taylor & Francis
Enteric bacterial infections contribute substantially to global disease burden and mortality,
particularly in the developing world. In vitro 2D monolayer cultures have provided critical …

Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations

F Ghiselli, B Rossi, A Piva, E Grilli - Frontiers in veterinary science, 2021 - frontiersin.org
Animal performance is determined by the functionality and health of the gastrointestinal tract
(GIT). Complex mechanisms and interactions are involved in the regulation of GIT …

[图书][B] Nanotechnology in agriculture and food science

MAV Axelos, M Van de Voorde - 2017 - books.google.com
A comprehensive overview of the current state of this highly relevant topic. An
interdisciplinary team of researchers reports on the opportunities and challenges of …

Cherry Extract from Prunus avium L. to Improve the Resistance of Endothelial Cells to Oxidative Stress: Mucoadhesive Chitosan vs. Poly(lactic-co-glycolic acid) …

D Beconcini, A Fabiano, R Di Stefano… - International journal of …, 2019 - mdpi.com
Polyphenolic compounds contained in cherry extract (CE) are well known for their
antioxidant and anti-inflammatory properties. Unfortunately, most of these natural …