Microbial transformations of human bile acids
Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …
While the liver is responsible for the production of primary bile acids, microbes in the gut …
High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review
IJ Malesza, M Malesza, J Walkowiak, N Mussin… - Cells, 2021 - mdpi.com
The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …
The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
The role of bile acids in carcinogenesis
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …
A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers
M Fidelle, C Rauber, C Alves Costa Silva, AL Tian… - Science, 2023 - science.org
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1)
blockade in cancer patients, but the mechanisms underlying their immunosuppressive …
blockade in cancer patients, but the mechanisms underlying their immunosuppressive …
[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
Diversification of host bile acids by members of the gut microbiota
JA Winston, CM Theriot - Gut microbes, 2020 - Taylor & Francis
Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host
hepatocytes synthesize primary bile acids from cholesterol. Once these host-derived primary …
hepatocytes synthesize primary bile acids from cholesterol. Once these host-derived primary …
Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer
H Zeng, S Umar, B Rust, D Lazarova… - International journal of …, 2019 - mdpi.com
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …
Bile acid signaling in inflammatory bowel diseases
Bile acids are a group of chemically different steroids generated at the host/microbial
interface. Indeed, while primary bile acids are the end-product of cholesterol breakdown in …
interface. Indeed, while primary bile acids are the end-product of cholesterol breakdown in …
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism
S Dong, M Zhu, K Wang, X Zhao, L Hu, W Jing… - Pharmacological …, 2021 - Elsevier
Recent studies show that the nutraceutical supplement dihydromyricetin (DHM) can alleviate
IBD in murine models by downregulating the inflammatory pathways. However, the …
IBD in murine models by downregulating the inflammatory pathways. However, the …