The advantages and challenges of using endolysins in a clinical setting

E Murray, LA Draper, RP Ross, C Hill - Viruses, 2021 - mdpi.com
Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional
antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes …

Endolysin, a promising solution against antimicrobial resistance

M Rahman, W Wang, Q Sun, JA Shah, C Li, Y Sun, Y Li… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications

Z Drulis-Kawa, G Majkowska-Skrobek… - Current Protein and …, 2012 - ingentaconnect.com
The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …

Bacteriophage endolysins: applications for food safety

M Schmelcher, MJ Loessner - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Endolysins are promising agents for detection and control of foodborne
pathogens.•Cell wall binding domains can be used for specific detection of bacteria in …

Potential for bacteriophage endolysins to supplement or replace antibiotics in food production and clinical care

MJ Love, D Bhandari, RCJ Dobson, C Billington - Antibiotics, 2018 - mdpi.com
There is growing concern about the emergence of bacterial strains showing resistance to all
classes of antibiotics commonly used in human medicine. Despite the broad range of …

Factors determining phage stability/activity: challenges in practical phage application

E Jończyk-Matysiak, N Łodej, D Kula… - Expert review of anti …, 2019 - Taylor & Francis
Introduction: Phages consist of nucleic acids and proteins that may lose their activity under
different physico-chemical conditions. The production process of phage formulations may …

Effective removal of staphylococcal biofilms on various food contact surfaces by Staphylococcus aureus phage endolysin LysCSA13

Y Cha, B Son, S Ryu - Food microbiology, 2019 - Elsevier
Staphylococcal biofilms are recognized as a significant problem in the food industry
because of their high resistance to antibiotics, and the use of bacteriophages or endolysins …

Bacteriophage-derived endolysins applied as potent biocontrol agents to enhance food safety

Y Chang - Microorganisms, 2020 - mdpi.com
Endolysins, bacteriophage-encoded enzymes, have emerged as antibacterial agents that
can be actively applied in food processing systems as food preservatives to control …

Lytic activity of the Vibrio cholerae type VI secretion toxin VgrG-3 is inhibited by the antitoxin TsaB

TM Brooks, D Unterweger, V Bachmann… - Journal of Biological …, 2013 - ASBMB
The type VI secretion system (T6SS) of Gram-negative bacteria has been implicated in
microbial competition; however, which components serve purely structural roles, and which …

Phages and enzybiotics in food biopreservation

J Ramos-Vivas, M Elexpuru-Zabaleta, ML Samano… - Molecules, 2021 - mdpi.com
Presently, biopreservation through protective bacterial cultures and their antimicrobial
products or using antibacterial compounds derived from plants are proposed as feasible …