A comprehensive review of caged phosphines: synthesis, catalytic applications, and future perspectives

H Shet, U Parmar, S Bhilare, AR Kapdi - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
Phosphines have played an important role in the rapid rise of transition metal-catalysed
processes and with the possibility of fine-tuning the electronic and steric properties of these …

Discovery, synthesis, and scale-up of efficient palladium catalysts useful for the modification of nucleosides and heteroarenes

S Bhilare, H Shet, YS Sanghvi, AR Kapdi - Molecules, 2020 - mdpi.com
Nucleic acid derivatives are imperative biomolecules and are involved in life governing
processes. The chemical modification of nucleic acid is a fascinating area for researchers …

Quadrol-Pd (ii) complexes: phosphine-free precatalysts for the room-temperature Suzuki–Miyaura synthesis of nucleoside analogues in aqueous media

JL Serrano, S Gaware, JA Pérez, J Pérez… - Dalton …, 2022 - pubs.rsc.org
Commercially available Quadrol, N, N, N′, N′-tetrakis (2-hydroxypropyl) ethylenediamine
(THPEN), has been used for the first time as a N^ N-donor neutral hydrophilic ligand in the …

Rapid plugged flow synthesis of nucleoside analogues via Suzuki-Miyaura coupling and heck Alkenylation of 5-Iodo-2'-deoxyuridine (or cytidine)

S Gaware, S Kori, JL Serrano, R Dandela… - Journal of Flow …, 2023 - Springer
Nucleosides modification via conventional cross-coupling has been performed using
different catalytic systems and found to take place via long reaction times. However, since …

Scale-up of a Heck alkenylation reaction: Application to the synthesis of an amino-modifier nucleoside 'Ruth linker'

S Bhilare, S Kori, H Shet, G Balaram, K Mahendar… - …, 2020 - thieme-connect.com
Ruth linker is a C5 pyrimidine modified nucleoside analogue widely utilized for the
incorporation of a primary amine in a synthetic oligonucleotide. The increasing demand for …

PTABS: a unique water-soluble π-acceptor caged phosphine

R Sahu, AR Kapdi - Synlett, 2023 - thieme-connect.com
Caged phosphines have unique structures and provide many advantageous properties that
can be fine-tuned to develop efficient catalytic systems. Our research group recently …

1, 3, 5‐Triaza‐7‐phosphaadamantane (PTA) Derived Caged Phosphines for Palladium‐Catalyzed Selective Functionalization of Nucleosides and Heteroarenes

SS Murthy Bandaru, S Bhilare, C Schulzke… - The Chemical …, 2021 - Wiley Online Library
Phosphines have, in combination with transition metals, played a pivotal role in the rapid
development of efficient catalytic processes. Caged phosphines constitute a class of three …

Water‐Soluble Pd‐Imidate Complexes as Versatile Catalysts for the Modification of Unprotected Halonucleosides

JL Serrano - The Chemical Record, 2022 - Wiley Online Library
Modification of unprotected nucleosides has been attracting continuous interest, since these
building blocks themselves and their phosphate‐upgraded corresponding nucleotides have …

[HTML][HTML] Na2 [Pd (saccharinate) 4]: A new phosphine-free water-soluble catalyst with singular structure for modification of ribose nucleosides at room temperature

JL Serrano, J Pérez, JA Pérez, I da Silva, R Sahu, K Pal… - Catalysis Today, 2024 - Elsevier
The easy synthesis of the anionic palladium catalyst containing saccharinate as only ligand
Na 2 [Pd (saccharinate) 4](I), starting from either Na 2 [PdCl 4] or Pd (AcO) 2, is reported …

An expedient approach to pyrazolo [3, 4-b] pyridine-3-carboxamides via palladium-catalyzed aminocarbonylation

RM Alam, JJ Keating - Synthesis, 2021 - thieme-connect.com
Pyrazolo [3, 4-b] pyridine is a privileged scaffold found in many small drug molecules that
possess a wide range of pharmacological properties. Efforts to further develop and exploit …