One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

Ovarian cancer is a highly metastatic disease and the leading cause of death from
gynecologic malignancy. Hence, and understanding of the molecular changes associated …

There is increasing evidence that some cancers are hierarchically organized, sustained by a
relatively rare population of cancer-initiating cells (C-ICs). Although the capacity to initiate …

Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in
regulating a variety of cellular processes, including cellular growth, senescence …

Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and
progression of many cancer types, including leukemia. However, the ID1 protein has not yet …

Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate,
acquire the ability to proliferate, and invade the extracellular matrix. In addition, Id-1 is …

Chemoresistance is one of the major reasons leading to ovarian cancer high mortality and
poor survival. Studies have shown that the alteration of cellular autophagy is associated with …

Id‐1 is an important regulator of cellular growth and differentiation and controls malignant
progression of breast cancer cells. The aim of our study was to assess the clinical impact of …

Since the identification of Id proteins more than a decade ago, much work has demonstrated
their regulatory roles in development, cell fate and lineage determination, proliferation …