Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

The past few years has witnessed a booming market of protein and peptide drugs, owing to
their superior efficiency and biocompatibility. Parenteral route is the most commonly …

At the blood–brain barrier (BBB), claudin (Cldn)-5 is thought to be the dominant tight junction
(TJ) protein, with minor contributions from Cldn3 and-12, and occludin. However, the BBB …

The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

Nonalcoholic fatty liver disease (NAFLD) is demonstrated to be closely related to the
disorder of gut microbiota and the intestinal mucosal barrier. Luteolin is a natural flavonoid …

Pharmacological treatment of central nervous system (CNS) disorders is difficult, because
the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve …

Breakdown of the blood-brain barrier (BBB) precedes lesion formation in the brains of
multiple sclerosis (MS) patients. Since recent data implicate disruption of the small intestinal …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Therapeutic oligonucleotides (TOs) represent one of the most promising drug candidates in
the targeted cancer treatment due to their high specificity and capability of modulating …