[HTML][HTML] Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
M Fallah, A Davoodvandi, S Nikmanzar, S Aghili… - Biomedicine & …, 2021 - Elsevier
Silymarin contains a group of closely-related flavonolignan compounds including silibinin,
and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been …
and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been …
Understanding the prooxidant action of plant polyphenols in the cellular microenvironment of malignant cells: Role of copper and therapeutic implications
Plant derived polyphenolic compounds are considered critical components of human
nutrition and have shown chemotherapeutic effects against a number of malignancies …
nutrition and have shown chemotherapeutic effects against a number of malignancies …
Cu (II)-coumestrol interaction leads to ROS-mediated DNA damage and cell death: a putative mechanism for anticancer activity
Phytoestrogens have attracted considerable interest as natural alternatives to hormone
replacement therapy and their potential as cancer therapeutic agents. Among …
replacement therapy and their potential as cancer therapeutic agents. Among …
Calcitriol–copper interaction leads to non enzymatic, reactive oxygen species mediated DNA breakage and modulation of cellular redox scavengers in hepatocellular …
Calcitriol is the metabolically active form of Vitamin D and is known to kill cancer cells. Using
the rat model of DEN induced hepatocellular carcinoma we show that there is a marked …
the rat model of DEN induced hepatocellular carcinoma we show that there is a marked …
Physiological serum copper concentrations found in malignancies cause unfolding induced aggregation of human serum albumin in vitro
Malignancies are characterized by several drastic metabolic changes, one of which is a
progressive rise in the levels of serum copper. This rise in serum copper is documented …
progressive rise in the levels of serum copper. This rise in serum copper is documented …
Calcitriol reverses induced expression of efflux proteins and potentiates cytotoxic activity of gemcitabine in capan-2 pancreatic cancer cells
H Gilzad-Kohan, S Sani… - Journal of Pharmacy & …, 2017 - journals.library.ualberta.ca
Purpose. Efflux and influx proteins play a major role in chemo-resistance by affecting the net
cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein …
cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein …
Biochemical mechanisms and molecular interactions of vitamins in cancer therapy
Recently, the potential role of vitamins in cancer therapy has attracted considerable
research attention. However, the reported findings are inconsistent, with limited information …
research attention. However, the reported findings are inconsistent, with limited information …
Selective cytotoxic action and DNA damage by calcitriol-Cu (II) interaction: putative mechanism of cancer prevention
Background Vitamin D is known to play an important role in cancer-prevention. One of the
features associated with the onset of malignancy is the elevation of Cu (II) levels. The mode …
features associated with the onset of malignancy is the elevation of Cu (II) levels. The mode …
Causing DNA damage and stopping DNA repair–Vitamin D supplementation with Poly (ADP-ribose) polymerase 1 (PARP1) inhibitors may cause selective cell death …
A Rizvi, I Naseem - Medical Hypotheses, 2020 - Elsevier
Inhibitors of PARP1 are currently being used to treat malignancies and as maintenance
drugs post chemotherapy. Vitamin D has been shown to have an anticancer effect (mediated …
drugs post chemotherapy. Vitamin D has been shown to have an anticancer effect (mediated …
Calcitriol induced redox imbalance and DNA breakage in cells sharing a common metabolic feature of malignancies: Interaction with cellular copper (II) ions leads to …
Calcitriol is known to selectively kill malignant cells, however, not much is known about the
mechanism by which it kills malignant cells and spares the “normal” cells. Since elevation of …
mechanism by which it kills malignant cells and spares the “normal” cells. Since elevation of …