The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …

Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …

The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious
threat to the global public health. The viral protease that processes viral polyproteins during …

Dengue is a mosquito-borne viral hemorrhagic disease that is a major threat to human
health in tropical and subtropical regions. Here we report crystal structures of a peptide …

Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins. These compounds have a low molecular weight, making them penetrate …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages
by host and viral proteases in order to produce the individual proteins that constitute an …

West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae.
Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment …

Zika virus (ZIKV) has rapidly emerged as a global public health concern. Viral NS2B-NS3
protease processes viral polyprotein and is essential for the virus replication, making it an …

Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the
context of maternal infection during pregnancy. An important target for drugs combatting Zika …